copertina di Physiology and Pathology of chloride transporters and channels in the nervous system ...

Physiology and Pathology of chloride transporters and channels in the nervous system - From molecules to diseases

di Alvarez Leefmans - Delpire • 2009 • dettagli prodotto

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DESCRIZIONE

Ion channels are key to communication between cells, and particularly in the nervous system. The dysfunction of ion channels and receptors are on the basis of a large number of diseases. Recent findings from molecular neurobiology have shown that particularly chloride ions play a key role in nervous tissue functions such as synaptic inhibition, neuronal development, sensory transduction and homeostasis of brain fluids and electrolytes. The study of these anions has intensified in the past years and with the growth of molecular biology and the development of optical methods, a wealth of new information has emerged on the molecular structure and function of chloride channels and transporters. Dysfunction of these specialized membrane proteins is now known to underlie diverse neurological disorders. They have become pharmacological targets for the treatment of conditions as diverse as epilepsies, pain, neurogenic inflammation, tumor growth and invasion, and brain edema. This book, written by world leaders in the field, is the first to present our current knowledge about the function and dysfunction of the mechanisms by which chloride crosses the membranes of nerve, glial and epithelial cells. It also provides extensive information on state-of-the-art methods to study cell chloride regulation. The authors review their fields of expertise and put them into perspective so that others wishing to enter the field can recognize areas where more work is needed.