HLA in Health and disease

di Lechler - Warrens • 2000 • dettagli prodotto

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DESCRIZIONE

Reviews what is known about human leukocyte antigen (HLA) and its role in various diseases. An introductory section summarizes current knowledge on the structure, function, genetics, and evolution of the HLA system. This section clarifies the complex nomenclature and discusses the mechanisms underlying disease associations with HLA alleles. A second section deals with the importance of HLA in the context of different clinical specialties. Individual chapters describe the association between HLA polymorphism and each disease. A final section features material on laboratory practice in tissue typing and histocompatibility. This second edition takes into account advances in research since the first edition (titled HLA and Disease) was published in 1994.Table of Contents: Introduction to the HLA System:P. Travers, Structure of Class I and II Molecules.C.M. Milner, R.D. Campbell and J. Trowsdale, Molecular Genetics of the Human MHC.R.J. Baker and A.N. Warrens, The Biology of MHC Molecules.C. AuPeh, A.W. Purcell, and J. McCluskey, The Function of MHC Molecules: Antigen Presentation.T.J. Vyse and B. Morley, The Analysis of Genetic Susceptibility.A. Warrens, Appendix.A. Warrens and R. Lechler, Mechanisms of HLA and Disease Associations.Disease Associations:G.T. Nepom, HLA-Associations with Rheumatoid Arthritis.P. Bowness, HLA and the Spondylarthopathies.R. Phelps and A. Rees, The HLA Complex in Renal Disease.J. Hillert and A. Fogdell-Hahn, HLA Associations in Neurological Diseases.G.T. Nepom, Type 1 Diabetes (IDDM).A.P. Weetman, Endocrinology.L.M. Sollid, A. Spurkland, and E. Thorsby, HLA Associations in Gastrointestinal Diseases.J.S. Pulido and J.W. Steilein, HLA and the Eye.P.A. Glynne and N.M. Price, HLA and Infectious Diseases.M.C. Pickering, M. Perraudeau, and M. Walport, The Systemic Vasculitides, Systemic Lupus Erythematosus, and Sjögren's Syndrome.A. Friedman, Association of the HLA System with Dermatological Diseases.R. Baker and G. Opelz, HLA and Transplantation: Alloimmune Response and the Role of HLA Matching in Clinical Transplantation.P. Wright, V. Nimgaonkar, R. Ganguli, and R. Murray, Psychiatric Disease.Definition of HLA Polymorphism:J.J. van Rood, The History of the Discovery of HLA.P. Dyer, S. Martin, and R. Stanford, Serological Methods in HLA Typing.P. Mason and R. Lechler, Cellular Methods in Testing Histocompatibility.H. Erlich, PCR-Based Methods in HLA Typing.J. Bodmer, W.F. Bodmer, and S. Marsh, HLA Nomenclature: The Name of the Rose.R. Bontrop and J. Kaufman, Evolution of HLA Polymorphisms