Skin Cancer after Organ Transplantation

di Stockfleth - Ulrich • 2009 • dettagli prodotto

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DESCRIZIONE

Skin Cancer after Organ Transplantation presents the state-of-the-art knowledge of cutaneous malignancies following organ transplantation. The life promoting and life enhancing benefits of solid organ transplantation is a major medical advance, but at the cost of the life-long immunosuppression needed to prevent rejection of the donated organ. This induction and maintenance of impaired immunological surveillance is paralleled by a significant increase in the incidence of specific cancers, of which skin cancers are highest. The book is divided into four sections, providing a basic overview on transplantation medicine, different immunosuppressive agents and their impact on the skin’s immune system, epidemiology and pathophysiology of skin cancer, applicable prophylaxis and therapeutic measures.Table of contents Historical Perspective (Past Present Future).- Immunology of organ transplantation and allograft rejection.- Posttransplant Malignancies.- Kidney Transplantation.- Heart/lung Transplantation .- Liver Transplantation.- Bone Marrow Transplantation.- Other Transplants.- Immunosuppression.- Introduction and general issues.- Calcineurin inhibitors.- MMF/MMS.- m-TOR Inhibitors.- Azathioprine.- Corticosteroids.- FTY and other new drugs.- Induction therapies.- Tolerance induction.- Skin Immune System.- Posttransplant Malignancies General Overview.- Influence of organ and pre-existing disease.- Epidemiology and Region specific features.- Europe.- USA/Canada.- Australia/Asia.- Etiological factors in cutaneous carcinogenesis.- Introduction.- Photocarcinogenesis - DNA damage.- UV-induced immunosuppression.- Mechanisms related to immunosuppressive therapies.- Oncogenic viruses.- HPV Epidemiology.- UV-HPV Interactions.- HHV 8.- Molecular pathogenesis of BCC and SCC.- Genetic basis of melanoma.- Specific Skin Cancers.- Non-melanoma Skin Cancer.- Actinic keratosis.- Squamous cell carcinoma.- Basal cell carcinoma.- Malignancies in genitoanal area.- Malignant Melanoma.- Rare Skin Cancers.- Kaposi’s sarcoma.- Merkel cell carcinoma.- Cutaneous lymphomas.- Prophylaxis and Therapy.- Prophylaxis and screening pre-transplantation.- Aftercare - the multi disc-approach.- Patient education.- Sunscreens and sun protection.- Dosage and choice/combination of immunosuppression.- Surgical interventions.- Specific management of field cancerisation.- Destructive management.- Systemic Chemoprevention.- Management of metastatic skin cancers in OTR.- Index