Innovative Endocrinology of Cancer

di Berstein - Santen • 2009 • dettagli prodotto

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DESCRIZIONE

This volume is devoted to the new developments in such topics as mechanisms of hormonal carcinogenesis, epidemiology and risk factors, hormone production by tumor tissue and hormonal sensitivity of the latter, genesis, dichotomy and endocrinology of cancer in females, pharmacogenomics and proteomics in oncoendocrinology, biological core of hormonal and antihormonal therapy of cancer and its prevention.Table of contents Mechanisms of Hormone Carcinogenesis: Evolution of Views, Role of Mitochondria.- Adaptation to Estradiol Deprivation Causes Up-Regulation of Growth Factor Pathways and Hypersensitivity to Estradiol in Breast Cancer Cells.- Role of Endocrine-Genotoxic Switchings in Cancer and Other Human Diseases: Basic Triad.- Breast Development, Hormones and Cancer.- Epidemiology of Hormone-Associated Cancers as a Reflection of Age.- Obesity and Diabetes Epidemics: Cancer Repercussions.- Progesterone Receptor Action: Translating Studies in Breast Cancer Models to Clinical Insights.- Aromatase expression in women’s cancers.- Proteomics of Cancer of Hormone-Dependent Tissues.- Endogenous Hormone Levels and Risk of Breast, Endometrial and Ovarian Cancer: Prospective Studies.- Hormonal Heterogeneity of Endometrial Cancer.- Cell Cycle Machinery: Links with Genesis and Treatment of Breast Cancer.- Selective Estrogen Modulators as an Anticancer Tool: Mechanisms of Efficiency and Resistance.- Pharmacogenomics of endocrine therapy in breast cancer.- Prevention of breast cancer using SERMs.