Structural and Evolutionary Genomics - Natural Selection in Genome Evolution

DESCRIZIONE

Structural genomics is the study of the DNA of living organisms. Evolutionary genomics is the study of the history of the genome. These subjects are closely interlinked. They are approached in this book using as a guideline the investigations carried out in the author's laboratory, relevant literature is critically reviewed and some general conclusions are presented. The author and his collaborators have studied a vast number of genomes, ranging from prokaryotes to human, using different approaches, including physical chemistry of DNA, viral integration and molecular cytogenetics. As the subtitle indicates the book discusses the fundamental importance of natural selection in shaping genomes. In terms of numbers, neutral and nearly neutral mutations represent most mutations, but a " regional " control is exerted by natural selection (essentially negative or purifying selection). A " neo-selectionist " model is proposed for genome evolution.

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ISBN: 9780444521361

Titolo: Structural and Evolutionary Genomics - Natural Selection in Genome Evolution

Autori: Bernardi

Editore: Elsevier - Eng

Volume: Unico

Edizione: 2005

Lingua: Inglese

Finitura: Copertina flessibile

Misure: 16x24 cm

Pagine: 450

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