Drug Resistance in the Treatment of Cancer

di Pinedo - Giaccone - Sikora • 2007 • dettagli prodotto

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DESCRIZIONE

Reviews the mechanisms and clinical implications of drug resistance in cancer, considered to be the most significant obstacle to the cure of cancer today. Topics covered include multiple drug resistance and its reversal, topoisomerase drugs, apoptosis, dose intensity and escalation, gene therapy and haematopoietic support.Table of Contents List of contributorsSeries editor's prefaceAbbreviations1. Resistance mechanisms to antimetabolites Erdem Göker, Richard Gorlick and Joseph R. Bertino2. Resistance to antitumor alkylating agents and cisplatin Beverly A. Teicher and Emil Frei III3. The MDR genes Lyn Mickley and Antonio Tito Fojo4. Topoisomerase genes and resistance to topoisomerase inhibitors Giuseppe Giaccone5. Genes that modulate apoptosis: major determinants of drug resistance John A. Hickman6. Clinical implications of drug resistance Henk M. W. Verheul and Herbert M. Pinedo7. The reversal of multidrug resistance William S. Dalton8. Effect of dose and schedule on chemotherapeutic drug resistance David Fennelly, George Raptis, John P. A. Crown and Larry Norton9. Circumvention of drug resistance by high-dose chemotherapy in solid tumors Elisabeth G. E. de Vries, Wil Dolsma, Geke A. P. Hospers and Nanno H. Mulder10. Enhancing drug effectiveness by gene transfer Karol SikoraIndex.