Inherited Susceptibility to Cancer

di Foulkes • 2009 • dettagli prodotto

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DESCRIZIONE

Many cancers, both common and rare, are known to have a hereditary predisposition. First published in 1998, this important contribution to the literature of cancer genetics covers all the key issues, reviewing both the technology behind genetic risk assessment and the ethical dilemmas it poses.Table of Contents Part I. Ethical, legal and social issues, screening, counselling, gene and mutation detection: 1. The inherited basis of cancer Shirley Hodgson and Gareth Evans2. Screening for cancer in those at high risk as a result of genetic susceptibility Howard Cuckle3. Ethical and legal perspectives on inherited cancer susceptibility Bartha Maria Knoppers and Beatrice Godard4. Cancer genetics and public expectations Dorothy Nelkin5. Genetic counselling June Peters6. Cancer genetics in primary care Gene Feder and Michael Modell7. Genetic epidemiologic approaches to finding genes that influence susceptibility to cancer Pamela St. Jean and Nicholas Schork8. Mutation detection Louise Hosking, Karin Au and Philippe SchorkPart II. Hereditary contribution to cancer: site-by-site and special groups: 9. Cancers of the digestive system Tamar Flanders and William Foulkes10. Cancers of the breast, ovary and uterus William Foulkes and Steven Narod11. Cancers of the kidney and urothelium Eamonn Maher12. Cancers of the prostate and testes Steven Narod, Bonnie King and David Hogg13. The neurofibromatoses and other neuro-oncological syndromes Martin Ruttledge and Guy Rouleau14. Malignant melanoma Nicholas Hayward15. Non-melanoma skin cancer David Goudie16. Endocrine cancers Harriet Feilotter and Lois Mulligan17. Tobacco-related cancers of the respiratory and upper digestive tract Zoltan Trizna and Stimson Schantz18. Inherited abnormalities of DNA processing and predisposition to cancer A. Malcolm Taylor19. Childhood cancer Kathy Pritchard-Jones20. Late-breaking developments William Foulkes and Shirley HodgsonIndex.