Diagnostic Techniques in Hematological Malignancies

di Erber • 2010 • dettagli prodotto

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DESCRIZIONE

The diagnosis and monitoring of hematological malignancies is complex and requires a systematic approach. Morphology, cell phenotyping, cytogenetics and molecular genetics are essential, and the results must be integrated. Diagnostic Techniques in Hematological Malignancies details the principles and applications of each of these test types in the diagnosis of hematological malignancies in blood and bone marrow. The first section describes the test modalities – including methodological principles, data interpretation and limitations – and is illustrated by clinical examples. The second section focuses on the clinical entities, detailing the most appropriate tests for diagnosis, staging and monitoring of different hematological malignancies and includes test utilization to identify prognostic markers and potential therapeutic targets. With contributions from multiple international experts, this illustrated book is an essential resource for qualified and trainee hematologists, oncologists, and pathologists. It's a practical and useful guide, providing a rational and structured approach to the laboratory assessment of hematological malignancies.Table of Contents PrefacePart I. Diagnostic Techniques: 1. Morphology Wendy N. Erber2. Immunocytochemistry Wendy N. Erber3. Flow cytometry Maryalice Stetler-Stevenson and Constance M. Yuan4. Cytogenetics Christine J. Harrison and Claire Schwab5. Molecular genetics Ken MillsPart II. Hematological Malignancies: 6. The integrated approach to the diagnosis of hematological malignancies Mike A. Scott and Wendy N. Erber7. Acute lymphoblastic leukemia Elaine Coustan-Smith and Dario Campana8. Acute myeloid leukemia David Grimwade9. Mature B cell leukemias Constantine S. Tam and Michael J. Keating10. Mature T cell and natural killer-cell leukemias Kaaren K. Reichard and Kathryn Foucar11. Lymphoma Jennifer Herrick and Ahmet Dogan12. Plasma cell neoplasms Rafael Fonseca and Riccardo Valdez13. Chronic myeloid leukemia Emma J. Gudgin and Brian Huntly14. Myeloproliferative neoplasms Philip A. Beer and Anthony R. Green15. Myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms Raphael Itzykson, Hervé Roudot and Pierre FenauxIndex.