Apoptosis in Carcinogenesis and Chemotherapy - Apoptosis in cancer

di Chen - Lai • 2009 • dettagli prodotto

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DESCRIZIONE

The purpose of this book is to provide information on apoptotic processes involved in major neoplastic diseases and their translations into emerging anti-cancer strategies. The book is divided into 15 chapters, each of which will be focused on one particular cancer (breast, bladder, cervical, colorectal, esophageal, gastric, laryngeal, liver, lung, nasopharyngeal, pancreatic, prostate, thyroid, leukaemia and cutaneous malignant melanoma). A number of established leaders in the field have critically summarized the recent discoveries concerning apoptosis in a particular cancer and its potential for anti-cancer treatment. The book describes how the apoptosis plays a role in the specific carcinogen-induced cellular and molecular changes during the development of the cancer, and critically discusses how the emerging anti-cancer strategy can be built by the utilization of the specific carcinogen-related apoptotic pathway. Therefore, this book will be not only for laboratory-based molecular and cell biologists and biochemists in cancer research but also for clinical oncologists and those working in the pharmaceutical and biotechnological industries.Table of contents 1.Apoptotic Signaling Pathway and Resistance to Apoptosis in Breast Cancer Stem Cells2.Anti-cancer strategy of transitional cell carcinoma of bladder based on induction of different types of programmed cell deaths3.Apoptosis in Carcinogenesis and Chemotherapy of the Uterine Cervix4.Apoptosis in Colorectal Tumorigenesis and Chemotherapy5.Apoptosis In Cutaneous Melanoma6.Apoptosis in Carcinogenesis and Chemotherapy - Esophageal Cancer7.Molecular Targets in Gastric Cancer and Apoptosis8.Apoptosis and the Tumor Microenvironment in Hematologic Malignancies9.Hepatocellular carcinoma10.Apoptosis in the Development and Treatment of Laryngeal Cancer: Role of p53, Bcl-2 and Clusterin11.Cyclooxygenase-2 and its metabolites: implications for lung cancer therapy12.Roles of negative and positive growth regulators in nasopharyngeal carcinoma13.Cellular Signaling Mechanisms In Pancreatic Apoptosis14.Strategies to circumvent resistance to apoptosis in prostate cancer cells by Targeted necrosis15.Carcinogenesis and therapeutic strategies for thyroid cancer16.Abbreviations17.Subject index