Mortality and Maldevelopment - Part II : The Saga of Neural Tube Defects

di Kalter • 2009 • dettagli prodotto

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DESCRIZIONE

Congenital malformations are worldwide occurrences striking in every condition of society. These severe physical abnormalities which are present at birth and affecting every part of the body happen more often than usually realized, once in every 33 births. The most common, after heart defects, are those of the neural tube (the brain and spinal cord) which happen in as many as one in every 350 births. They have been noted as curiousities in man and beast throughout recorded history and received great attention in our time by various fields of study, for example, their faulty prenatal development by embryologists, familial patterns by geneticists, causation by environmentalists and variability by population scientists. Attention turned much in recent years to the relation of these malformations to deficiency of a particular dietary ingredient, folic acid, a subject this book analyzes in depth. The greatest conundrum of all, which this latest matter like so much else hinges on, is the amazing fact of the tremendous, almost universal decrease in the frequency of these anomalies since early in the 20th century. The puzzle is ‘What can this downward trend possibly mean?’ and at bottom ‘Whether it is part of a long-term cyclical pattern’. This fascinating biological phenomenon is explored in the book together with various other topics.Table of contents 1. Introduction: Basics2. Neural Tube Defects3. Setting the Stage4. Studies in the Old World5. The Continent of Europe6. The United States7. Geography and Chronology8. Canada9. Australia and New Zealand10. Blacks and Jews11. The Mideast12. Asia13. The Sex Ratio Phenomenon14. Abortion15. Fetal Diagnosis of Neural Tube Defect16. Etiology I: Early Questions17. Etiology II18. Neural Tube Defects in China19. The Ultimate Question20. The Future