copertina di The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes: Volume III ...

The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes: Volume III : Metabolic and Peripheral Biomarkers

di Ritsner • 2009 • dettagli prodotto

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DESCRIZIONE

Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer's disease, epilepsy, alcoholism, substance abuse and others are some of the most debilitating illnesses worldwide characterized by the complexity of causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures. Recent advances in neuroscience, genomic, genetic, proteomic and metabolomic knowledge and technologies have opened the way to searching biomarkers and endophenotypes, which may offer powerful and exciting opportunities to understand the etiology and the underlying pathophysiological mechanisms of neuropsychiatric disorders. The challenge now is to translate these advances into meaningful diagnostic and therapeutic advances.Table of contents ForewordContributorsPart I. Possible Metabolic and Peripheral Biomarkers1. Peripheral biomarkers in dementia and Alzheimers disease. Christian Humpel and Josef Marksteiner2. S100B as a potential neurochemical biomarker in a variety of neurological, neuropsychiatric and neurosurgical disorders. Jon Sen3. Can the cortisol to DHEA molar ratio be used as a peripheral biomarker for schizophrenia and mood disorders? Peter Gallagher and Michael S. Ritsner4. Neuroactive steroid biomarkers of alcohol sensitivity and alcoholism risk. A. Leslie Morrow and Patrizia Porcu 5. Neuroendocrine markers of psychopathy. Andrea L. Glenn6. Mitochondrial complex I as a possible peripheral biomarker for schizophrenia. Dorit Ben-Shachar7. Peripheral biomarkers of excitotoxicity in neurological diseases. Lucio Tremolizzo, Gessica Sala and Carlo Ferrarese8. Melatonin as a biological marker in schizophrenia. Armando L. Morera, Pedro Abreu-Gonzalez, Manuel Henry9. Peripheral biological markers for mood disorders. Ghanshyam N. Pandey and Yogesh Dwivedi10. The diagnosis of alcoholism through the identification of biochemical markers in hair. Nadia De Giovanni11. Retinoic acid signalling in neuropsychiatric disease: possible markers and treatment agents. Sarah J. Bailey and Peter J. McCaffery 12. Abnormalities of inositol metabolism in lymphocytes as biomarkers for bipolar disorder. Galila Agam, Yuly Bersudsky and Robert H. BelmakerAfterword by Robert H. BelmakerContents of Volumes 1, 2, and 4Contributors of Volumes 1, 2, and 4Index