Transgenic and Mutant Tools to Model Brain Disorders

di Kalueff • 2010 • dettagli prodotto

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DESCRIZIONE

As the presence of genetically modified animal models in research laboratories has multiplied, the role of genetic factors in the pathogenesis of brain disorders has become particularly important. The refinement of molecular genetic methods has continued to broaden our understanding of the genetic factors associated with a variety of disorders. In Transgenic and Mutant Tools to Model Brain Disorders, leading scientists specializing in this field contribute a timely collection of recent advances featuring a vast array of topics in order to contribute to the diverse approaches taken toward the evaluation of genetically modified models in biomedical research. Opening with several chapters covering general aspects of genetically modified animal models, the book then continues with detailed chapters on models of specific human brain disorders, including OCD, Rett Syndrome, anxiety disorders, depression, and schizophrenia. As a volume in the successful Neuromethods series, the chapters provide authoritative reviews covering the most commonly used approaches in the field.