Basic Principles of Drug Discovery and Development

di Blass • 2015 • dettagli prodotto

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DESCRIZIONE

The science of drug discovery covers a wide range of disciplines. This reference text explains that identifying a new drug in the modern era is a multifaceted endeavor that requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. It also describes enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine that have become critical to the successful development of marketable therapeutics.
Given the wide range of disciplines and techniques that are required for cutting edge drug discovery research, it is of paramount importance that scientists have both a mastery of their own fields and a fundamental understanding of their collaborator’s fields.
Basic Principles of Drug Discovery and Development provides an introduction to the fundamental principles of drug discovery and development, beginning with an historical overview of drug discovery. It then educates readers about important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. The textbook is designed so that upon completion of a one semester course, students will have been provided with a basic understanding of the drug discovery process.
This reference text provides a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor that is drug research. It is designed to enable a new scientist to rapidly understand the key fundamentals of drug discovery including pharmacokinetics, toxicology, intellectual property. As without a clear understanding, these knowledge gaps could lead to communication issues in a new scientist’s early career.
The text and related course material is designed for graduate students in chemistry, biology, pharmacology, biochemistry, pharmacology, toxicology, formulations, who are interested in either a career or to understand the discovery and development of new therapeutic agents with an interest in a career in drug discovery research. Also ideally suited for non-scientists who need to understand the pharmaceuticals industry.