Somatostatin Analogues: From Research to Clinical Practice

di Hubalewska Dydejczyk - Signore - De Jong - Dierckx - Buscombe - Van de Wiele • 2015 • dettagli prodotto

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DESCRIZIONE

The book covers the whole spectrum of issues related to the somatostatin and its analogues. The first part deals with the history of somatostatin discovery, the physiology of endogenous somatostatin family, its actions, receptors and receptors distribution in normal tissues as well as in malignancies and other pathologies. The next section is dedicated to the diagnostic application of radiolabeled somatostatin analogues. It describes the general concept of their application in imaging, gives detailed characteristics of available radiopharamaceuticals for both SPECT and PET, and focuses on the clinical entities in which such diagnostic modality is indicated. Future perspectives are also included. The following chapters provide the up-to-date information on the use of "cold" somatostatin analogues in pharmacotherapy: starting with detailed description of therapy-approved peptides, followed-up by an overview of their application in clinical practice: in acromegaly, neuroendocrine tumors and other pathologies, including non-malignant ones (i.e. gastric tract hemorrhage or diabetic retinopathy). The third section section deals with radiolabelled somatostatin analogues use in radioisotope therapy and covers description of the radiopharmaceuticals and isotopes for therapeutic purposes, dosimetry, dual-isotope therapy, clinical application particularly in disseminated neuroendocrine tumors. The last part of the book covers the preclinical and research issues: novel somatostatin receptor agonists, pansomatostatins, somatostatin receptor antagonist, dopastatins and coritstatins.